1. With 6-across, developer of a successful polio vaccine

6. See 1-across

10. Actors Gilliam and Erwin

14. Forward, to Fellini

16. "Je vous en ___"

17. Sprite of Irish folklore

18. Karl who discovered the major blood groups

20. Circa

21. ___ grecque (cooked in olive oil, lemon juice, wine and herbs, and served cold)

22. "___ had it!"

23. Peacock-feather spots

24. Father of modern chemotherapy

28. "Happy Days" hangout

31. "Norma ___"

32. "If ___ a Hammer"

33. Ad headline

34. Discoverer of streptomycin

38. ___ gestae

39. Indigenous Canadian

40. "Thar __ blows!"

41. "___ queen!" ("You go, girl!")

43. Silly fill-in-the-blanks story

45. DOJ division

47. Bela who developed a diphtheria test

51. "___ takers?"

52. Retired Manning

54. "Walk Away ___" (1966 hit)

55. NBA stat.

58. She was a 1988 Nobel winner for rational drug design

62. Zeus's war-loving son

64. Epstein-___ virus

65. "Kidnapped" author's inits.

66. Chinese menu general

67. First American-born woman to win a Nobel prize in medicine

70. Churchill successor

71. Actress Gardner

72. Chinese "way"

75. Taunt

76. He found a cure for syphilis

81. Pertaining to a duct gland

82. Spanish house

83. He was found in a spider hole

84. Aardvark fare

85. A citric acid "cycle" was named for him, with 86-across

86. See 85-across

1. Big name in yoga leggings

2. Elliptical

3. "Peter Pan" dog

4. "Go on..."

5. John, Paul and George: abbr.

6. Detected

7. Prince Valiant's son

8. Fib

9. Plop preceder

10. Dries out, with "up"

11. Strip of clickable icons

12. Tiny Tim's instrument

13. Works of Swift and Wilde

15. "___ ancient Mariner..."

17. Cousin of an agouti

19. Number of times a website has been visited

23. "End ___" (1999 Schwarzenegger action-horror film)

25. This comes before kiger, humara or sertig in sneakers

26. Puzzled reactions

27. Candied veggie

28. "___ sure you're aware"

29. Olin of "Chocolat"

30. "He __ into third." (Dizzy Dean)

31. PG-13, e.g.

35. Leon Uris's "___ 18"

36. "I knew it!"

37. Mother-of-pearl materials

42. Author Silverstein

44. "So long"

46. Avian ___

48. "What's ___ for me?"

49. Boardroom VIPs

50. Bingolike casino game

53. Cyndi Lauper "___ All Night"

55. Indian flatbread

56. Kind of shake or bar

57. Unified whole, in psychology

59. Amscrayed

60. "Don't give up!"

61. River and community on the edge of the Olympic National Park

63. Spicy dips or Latin dances

68. Bad look

69. Much of "Deck the Halls"

72. All alternative

73. Hail ___ (cry, "Taxi!")

74. Units of resistance

76. SR 1 through Malibu

77. Tiny battery size

78. Admiral's org.

79. Outfitters based in Calhoun, Ga.

80. Person in charge: abbr.